How to Use AI in Cold Email Campaigns for Clients

photo of Alice Zaiceva from Setupad

Have you used AI to help you out with cold outreach campaigns for your clients? It seems everyone and their mother are testing the hottest new AI-powered tools right now. And it’s no different for lead gen agencies.

We’ve invited our pals from Setupad to share how you as an agency can power up the campaigns you’re sending on behalf of your clients with AI. Let’s dive in.


Breaking through the cluttered inboxes of your clients’ prospective customers presents a formidable challenge. Fortunately, a dose of AI-backed personalization and strategic insight can help you out. Welcome to the realm of AI-powered cold email campaigns.

By harnessing the power of AI in your cold email campaigns, you can engage your clients more effectively, boost conversion rates, and drive substantial business growth.

In this article, I’ll delve into the potential of AI-driven cold emails and provide valuable insights into leveraging them effectively for your agency.

How to use AI into your cold email campaigns

The introduction of AI has revolutionized these campaigns, optimizing and enhancing their effectiveness in various ways. For instance, AI can analyze the best time to send prospecting emails, improving open rates and responses. AI prospecting tools provide advanced analytics, enabling more effective cold email marketing dynamics.

Additionally, AI email assistants can automate the process of writing emails, making prospect email marketing more efficient. Some free cold email software even incorporates AI to streamline the process. The use of AI in cold email campaigns, often referred to as ‘cold AI,’ is transforming how businesses approach email prospecting and implement prospecting email best practices. It’s clear that AI for mail writing, particularly in the context of cold emails, is an area of growth and innovation.

Leveraging AI for client-centric content

A great cold email campaign relies on personalization. AI-powered software can help you achieve this with ease: it provides tailored content that addresses each recipient’s unique needs and aligns your message to their interests. While traditional email tools allow for personalization using custom fields like the recipient’s name or company they work in, AI-driven personalization is capable of achieving more.

Cold email tools often have features for importing and managing contact lists. AI email tools can enhance this process by providing data enrichment services.

Benefits of personalized content for clients

Personalized content can have a positive impact on any email campaign, but the benefits are especially pronounced for client-centric campaigns. This includes:

  • Hyperpersonalization: Because AI analyzes vast amounts of data, their can segment your audience into highly specific groups based on beahavior, interests, and preferences, allowing for hyperpersonalized campaigns.
  • Improved response rate: AI can also optimize timing of email for each recipient taking into account their historical engagement patterns, increasing the likelihood of a response.
  • Enhanced segmentation: AI analyzes vast amounts of data about each recipient, including their past interactions with your emails, website visits, and social media activity.

AI data analysis

AI’s role in data analysis for prospecting is pivotal. It sifts through voluminous data, identifying patterns and insights that are crucial for prospecting. This intelligence helps in precise targeting, making your cold emails resonate better with potential clients and nurture their loyalty, whilst also improving the response rate.

AI analytics measurement

AI analytics uses machine learning algorithms to analyze the sentiment of email responses, helping gauge the emotional impact of campaigns and adjust your messaging accordingly. Natural language processing (NLP) algorithms can scan email replies for specific keywords or phrases, giving you valuable insights into customer feedback, pain points, or areas of interest.

Cold email A/B testing and optimization

You already know that a key element of successful cold email campaigns is testing and optimization. AI-powered tools can help you identify the elements that work best for your emails. This includes tweaking headlines, body content, images, calls to action, and more – all with minimal manual effort.

While AI can suggest variations for subject lines, email copy, CTAs, and other elements based on past performance data, Woodpecker can help implement these suggestions in a user-friendly interface where you can conduct A/B tests to determine the most effective combinations.

A/B testing in email campaigns

Using AI-driven A/B testing, you can compare different versions of emails to determine the best approach for each recipient. AI can analyze a wide range of variables simultaneously, such as subject lines, email copy, images, and even send times, to determine the most effective combinations.

Automation for outreach

AI-driven automation can also help optimize your outreach. By analyzing user behavior, AI tools can identify trends and insights that guide you in crafting the most compelling messages for each audience segment. Machine learning algorithms can learn from past A/B test results and continually refine your email content to maximize engagement and conversion rates.

Automation for follow-ups

AI-driven automation can also help you in managing follow-up emails. AI-powered software such as SaneBox can analyze email responses and automatically send follow-up emails at the right time, increasing the effectiveness of your campaigns. Use it together with cold email tools to automate follow-up sequences, and use AI to optimize the timing and content of these follow-ups.

Cold email personalization

The power of AI for personalization is not to be underestimated. AI-powered tools can help you automate the generation of personalized emails at scale, making it possible to send thousands of highly tailored messages without breaking a sweat.

Again, it’s great to use these tools together with cold email tools. AI tools can help personalize email content by helping you to collect recipient-specific information, while cold email platforms like Woodpecker can provide placeholders for personalized elements, such as {{FIRST NAME}} or {{COMPANY}}, which get then populates with the relevant data before sending.

Dynamic email content generation

AI-driven tools can help you generate dynamic email content based on the recipient’s data. Dynamic content generation ensures that each email is tailored to the individual recipient, including not only their name but also relevant product recommendations, content suggestions, or even personalized subject lines.

Impact of personalization on client engagement

Personalization has a huge impact on client engagement. AI-driven personalization makes it possible to craft emails that are highly relevant to recipients, leading to higher open and click-through rates. This is key in ensuring that your campaigns stand out from the crowd.

Analytics and performance measurement

Of course, no email campaign is complete without performance measurement. Without metrics, it’s impossible to evaluate whether your efforts are paying off.

AI-driven analytics tools for campaign performance evaluation

Cold email tools (like Woodpecker Agency) already offer a wealth of valuable insights, such as open rates, click-through rates, bounce rates, engagement – all in real time. What AI-driven analytics tools can help you with, is to track user engagement across multiple channels, including email, social media, and website interactions, providing a holistic view of the customer journey. This allows you to monitor the progress of your campaigns and take necessary steps for optimization.

Key metrics and KPIs

So, what are the key metrics and KPIs that you should be tracking in order to measure success? Here’s a quick overview:

  • Open rate
  • Click-through rate (CTR)
  • Conversion rate
  • Response rate
  • Bounce rate
  • Unsubscribe rate

By tracking these metrics, you can ensure that your cold email campaigns are optimized and performing at their best.

Example ChatGPT prompts for cold emailing

Understanding the power of AI-driven cold emails is one thing. But how do you actually get started?

A good idea is to start by utilizing effective frameworks, like AIDA (Attention, Interest, Desire, Action). A full guide on using cold email frameworks with AI can be found here.

Here are a few prompts you can use on Chat GPT to start creating cold emails today:

  • “Can you help me draft a cold email to a potential client introducing our new software product and highlighting its unique features?”
  • “Could you please write a cold email for me to reach out to an influencer in the fitness industry, proposing a collaboration for our new wellness product?”
  • “I’m trying to get in touch with a prospective business partner. Can you help me write a compelling cold email that outlines our common interests and proposes a meeting?”
  • “Can you assist in crafting a cold email to a potential investor, introducing our innovative startup idea and expressing interest in discussing it further?”

These will give you good starting-point cold emails that you can then tweak and make better. More effective prompts can be found here.

Considerations when using AI-generated email copy

It’s important to know that AI is a great starting point for generating cold email copy, but it’s only a tool. You still need to edit your copy to sound more conversational and less robotic. Check the facts. And make sure the tone aligns with your brand and audience.

Avoid clear AI-generated opening lines, such as “I hope this email finds you well”. Phrases like this instantly give away AI (or an inexperienced cold email sender!).

Insert anecdotes, personal experiences, or storytelling elements that create a more human connection in the email. This can make your message more relatable and engaging.

Finally, add a clear and persuasive CTA that prompts the recipient to take action. AI can generate suggestions, but customize it to fit the email’s context.

6 best AI email prospecting tools

Now that you understand the fundamentals of AI-powered cold email campaigns, let’s take a look at some of the best cold email AI tools specifically designed for optimizing and streamlining your client outreach.


Clearbit is a dynamic prospecting tool that integrates AI to supercharge your cold email campaigns. Its compelling features include real-time updating of leads, comprehensive prospect information, and seamless integration with your existing email platforms. With Clearbit, the personalization of emails is effortless, enhancing client engagement and boosting conversion rates.


Clearout is an AI-powered prospecting tool that enriches prospect records with real-time data, providing essential context for every lead, contact, and account. It offers a Chrome extension that automates list building on LinkedIn. It also offers a web-app with 15+ filters like industry and role to help you build a highly targeted list.


Phrasee is an AI-driven platform that excels in optimizing email subject lines to grab audience attention. The tool leverages machine learning and natural language processing to generate and test the most effective subject lines, resulting in improved open and click-through rates. Its predictive capabilities forecast future email campaign performance based on historical data, helping you plan more effective campaigns.

Seventh Sense

Seventh Sense is an innovative AI-powered platform designed to optimize the timing and frequency of your email campaigns. It uses artificial intelligence to analyze recipient behavior, thereby identifying the best times to send emails for maximum engagement. This leads to improved open rates, click-through rates, and, ultimately, conversion rates.


Zeta is a high-performance AI email marketing tool that focuses on customer lifecycle management. It integrates comprehensive data, predictive analytics, and proprietary machine learning algorithms to enhance customer acquisition, retention, and growth. By providing personalized content it improves engagement rates, driving higher conversions and ROI.


Smartwriter.AI is an advanced AI tool designed to revolutionize cold email campaigns. It uses AI algorithms to generate highly personalized emails, adding a human touch to automated communications. It excels at creating targeted prospecting emails, fostering higher engagement, and improving conversion rates. Its robust features offer streamlined email marketing, accelerating your business growth.


AI-driven cold email campaigns are a great way to reach out to potential clientele and build meaningful relationships. AI tools such as Clearbit, Phrasee, Seventh Sense, Zeta, and Smartwriter.AI make it easy to craft personalized emails that ensure maximum engagement and improved conversions. With the right approach and a bit of help from AI, you can take your email prospecting campaigns to new heights.


What are email marketing tools and how do they benefit marketing teams?

Email marketing tools are software platforms designed to assist marketing teams in creating, sending, and analyzing marketing emails. These tools help in leveraging user data to tailor campaigns, ensuring better engagement and effectiveness of marketing efforts.

How do AI email marketing tools enhance email marketing strategies?

AI email marketing tools enhance email marketing strategies by using artificial intelligence to analyze customer data, suggest subject lines, and optimize email content. This leads to more personalized and effective marketing campaigns, improving overall engagement and conversion rates.

What is the impact of invalid email addresses on email marketing?

Invalid email addresses can significantly impact email marketing by reducing email deliverability and skewing campaign analytics. They can lead to higher bounce rates, potentially affecting the sender’s reputation and the effectiveness of future email campaigns.

Can AI in email marketing improve email deliverability?

Yes, AI in email marketing can improve email deliverability by identifying risky sending patterns and optimizing outgoing messages to avoid spam filters. AI technology can also provide deliverability insights, helping marketers refine their strategies for better results.

What are some effective email marketing strategies for today’s market?

Effective email marketing strategies for today’s market include personalized content marketing, segmentation of customer data, A/B testing, and integration of AI technology for enhanced analysis and automation. These strategies help in creating more relevant and engaging marketing emails.

How does AI-based email marketing differ from traditional email marketing?

AI-based email marketing differs from traditional email marketing in its ability to leverage big data and natural language generation for creating more personalized and effective campaigns. AI can automate complex tasks, save time, and provide deeper insights into email performance.

Why is email validation important in email marketing?

Email validation is crucial in email marketing as it helps prevent invalid email addresses from entering the database. This ensures higher deliverability rates, better campaign accuracy, and protects the sender’s reputation by reducing bounce rates.

What role does artificial intelligence play in email marketing software?

Artificial intelligence in email marketing software plays a role in automating tasks, analyzing customer data, and providing predictive insights. AI features can suggest optimal sending times, content preferences, and even generate AI-powered images adhering to brand guidelines.

How can an email marketing platform help in marketing automation?

An email marketing platform can help in marketing automation by streamlining the process of creating, sending, and analyzing marketing campaigns. It allows for scheduling emails, segmenting audiences, and integrating with other marketing tools for a cohesive strategy.

What should email marketers consider when choosing an email marketing tool?

Email marketers should consider factors like ease of use, AI features, integration capabilities, analytics, and deliverability insights when choosing an email marketing tool. The tool should align with the marketing team’s goals and be capable of scaling with the business.

How will AI technology shape the future of email marketing?

AI technology will shape the future of email marketing by offering more advanced predictive analytics, real-time API scans for optimizing campaigns, and enhanced personalization through natural language generation. AI will enable marketers to create more targeted, effective, and efficient email marketing campaigns.